2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
- Product Name
- 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
- CAS No.
- 192718-06-2
- Chemical Name
- 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
- Synonyms
- C527;C527 >=98% (HPLC);2-(4-Fluorophenyl)phtho[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione;Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-;Inhibitor,C 527,DUBs,C527,Deubiquitinase,C-527,inhibit
- CBNumber
- CB62719612
- Molecular Formula
- C17H8FNO3
- Formula Weight
- 293.25
- MOL File
- 192718-06-2.mol
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Property
- Boiling point:
- 488.6±47.0 °C(Predicted)
- Density
- 1.433±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO: soluble0.3mg/mL, clear (warmed)
- pka
- -4.21±0.20(Predicted)
- form
- powder
- color
- faint yellow to dark yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1008
- Product name
- C527
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $107
- Updated
- 2022/05/15
- Product number
- 21771
- Product name
- C527
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 21771
- Product name
- C527
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- 21771
- Product name
- C527
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $317
- Updated
- 2024/03/01
- Product number
- 21771
- Product name
- C527
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $435
- Updated
- 2024/03/01
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Chemical Properties,Usage,Production
Biological Activity
C527 is a pan-DUB enzyme inhibitor with high activity against USP1/UAF1 complex with IC50 value of 0.88 μM.
in vitro
Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC 50 of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro . However, the IC 50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents.
target
0.88 μM (USP1)
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Preparation Products And Raw materials
Raw materials
Preparation Products
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Suppliers
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